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Canine CD46 Protein (CD4-DM146) Summary
Product Description |
Recombinant Canine CD46 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Cys45-Gly344. |
Product Background |
CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in preventing complement deposition on host tissue is underpinned by the fact that deficiency of CD46 is a predisposing factor for numerous disease conditions arising from complement-mediated 'self-attack'. |
Product Category |
Recombinant Protein / Antibody discovery / ADC targets |
Canine CD46 Protein (CD4-DM146) Specifications/Details
Protein |
CD46 |
Synonyms |
TLX; CD46; MCP; MIC10; AHUS2; TRA2.10; Membrane cofactor; LOC609365 |
Accession |
|
Species |
Canine |
Biotinylated |
no |
Amino Acid Range |
Cys45-Gly344 |
Molecular Weight |
The protein has a predicted MW of 34.11 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Canine CD46 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Canine CD46 is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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