Cynomolgus ALCAM/CD166 Protein (ALC-CM101)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Cynomolgus ALCAM, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Anti-ALCAM Antibody, hFc Tag with the EC50 of 0.62ug/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Trp28-Lys527

Catalog: ALC-CM101

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Product Description Recombinant Cynomolgus ALCAM/CD166 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Trp28-Lys527.

Product Background

Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis.Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM.

Product Category

Recombinant Protein

Target

ALCAM/CD166

Gene/Protein ID

G7NZQ8

Species

Cynomolgus

Exact Sequence

Trp28-Lys527
Molecular Weight The protein has a predicted MW of 57.10 kDa. Due to glycosylation, the protein migrates to 70-85 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Cynomolgus ALCAM, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Anti-ALCAM Antibody, hFc Tag with the EC50 of 0.62ug/ml determined by ELISA. See testing image for detail.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Cynomolgus ALCAM, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Anti-ALCAM Antibody, hFc Tag with the EC50 of 0.62ug/ml determined by ELISA.
The purity of Cynomolgus ALCAM is greater than 95% as determined by SEC-HPLC.
Cynomolgus ALCAM on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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