Cynomolgus CDH17/Cadherin 17 Protein (CDH-CM127)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
  • Activity: Immobilized Cynomolgus CDH17, His Tag at 0.5 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 6.5 ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Gln23-Thr784

Catalog: CDH-CM127

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Product Description Recombinant Cynomolgus CDH17/Cadherin 17 Protein is expressed from HEK293 with His tag at the C-terminus.; It contains Gln23-Thr784.

Product Background

Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Product Category

Recombinant Protein

Target

CDH17/Cadherin 17
Accession

Species

Cynomolgus

Exact Sequence

Gln23-Thr784
Molecular Weight The protein has a predicted MW of 85.57 kDa. Due to glycosylation, the protein migrates to 95-115 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Cynomolgus CDH17, His Tag at 0.5 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 6.5 ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin Less than 1 EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Cynomolgus CDH17, His Tag at 0.5 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 6.5 ng/ml determined by ELISA.
The purity of Cynomolgus CDH17 is greater than 95% as determined by SEC-HPLC.
Cynomolgus CDH17 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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