Name: Cynomolgus CDH17/Cadherin 17 Protein (CDH-CM127)
Brand: KactusBio
SKU: CDH-CM127-100UG
Price: 379.5 USD
Availability: InStock

Cynomolgus CDH17/Cadherin 17 Protein (CDH-CM127)

Immobilized Cynomolgus CDH17, His Tag at 1 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 2.2 ng/ml determined by ELISA (QC Test).

Cynomolgus CDH17 on Bis-Tris PAGE under reduced condition. The purity is greater than 90%.

Loaded Anti-CDH17 Ab., hFc-Avi Tag on ProA-Biosensor can bind Cynomolgus CDH17, His Tag with an affinity constant of 9.78 nM as determined in BLI assay (Gator® Prime).

The purity of Cynomolgus CDH17 is greater than 90% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: > 90% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Activity: Immobilized Cynomolgus CDH17, His Tag at 1 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 2.2 ng/ml determined by ELISA (QC Test).
Amino Acid Range: Gln23-Thr784

Catalog #CDH-CM127

Size

100UG

500UG

Order by 4pm ET for delivery on:

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Cynomolgus CDH17/Cadherin 17 Protein (CDH-CM127) Summary

Product Description	Recombinant Cynomolgus CDH17/Cadherin 17 Protein is expressed from HEK293 with His tag at the C-terminus.; It contains Gln23-Thr784.
Product Background	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Product Category	Recombinant Protein / Antibody discovery / ADC targets

Cynomolgus CDH17/Cadherin 17 Protein (CDH-CM127) Specifications/Details

Protein	CDH17/Cadherin 17
Synonyms	Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16;
Accession	XP_005563762.2
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Gln23-Thr784
Molecular Weight	The protein has a predicted MW of 85.57 kDa. Due to glycosylation, the protein migrates to 95-115 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus CDH17, His Tag at 1 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 2.2 ng/ml determined by ELISA (QC Test).
Product Tag	C-His
Expression System	HEK293
Purity	> 90% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Immobilized Cynomolgus CDH17, His Tag at 1 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 2.2 ng/ml determined by ELISA (QC Test).
	Cynomolgus CDH17 on Bis-Tris PAGE under reduced condition. The purity is greater than 90%.
	Loaded Anti-CDH17 Ab., hFc-Avi Tag on ProA-Biosensor can bind Cynomolgus CDH17, His Tag with an affinity constant of 9.78 nM as determined in BLI assay (Gator® Prime).
	The purity of Cynomolgus CDH17 is greater than 90% as determined by SEC-HPLC.