Cynomolgus CEACAM-5/CD66e Protein (CAM-CM105)
Cynomolgus CEACAM-5/CD66e Protein (CAM-CM105)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Gln35-Gly685
  • Other Available Proteins:
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Catalog #CAM-CM105
Regular price $297.00
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Cynomolgus CEACAM-5/CD66e Protein (CAM-CM105) Summary

Product Description

Recombinant Cynomolgus CEACAM-5/CD66e Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln35-Gly685.

Product Background

Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver. CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites. Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors, and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated.

Product Category

Recombinant Protein / Antibody discovery / CAR-T targets | ADC targets

Cynomolgus CEACAM-5/CD66e Protein (CAM-CM105) Specifications/Details

Protein
CEACAM-5/CD66e
Synonyms
CEACAM-5; CD66e; CEA; Meconium antigen 100; Carcinoembryonic; CEACD66e; DKFZp781M2392
Accession
Species
Cynomolgus
Biotinylated
no
Amino Acid Range
Gln35-Gly685
Molecular Weight
The protein has a predicted MW of 72.76 kDa. Due to glycosylation, the protein migrates to 120-200 kDa based on Bis-Tris PAGE result.
Product Tag
C-His

Fluorophore

Unconjugated
Expression System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Cynomolgus CEACAM-5 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Cynomolgus CEACAM-5 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Cynomolgus CEACAM-5 is greater than 95% as determined by SEC-HPLC. The purity of Cynomolgus CEACAM-5 is greater than 95% as determined by SEC-HPLC.
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