Cynomolgus LILRB2/CD85d/ILT4 Protein (LIL-CM1B2)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 852 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Gly24-Arg457
Catalog #LIL-CM1B2
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Product Description
 Recombinant Cynomolgus LILRB2/CD85d/ILT4 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gly24-Arg457.
Product Background
 The immunoglobulin-like transcript (ILT) comprise a family of activating and inhibitory type immunoreceptors whose genes are located in the same locus that encodes killer cell Ig-like receptors (KIR). ILT4, also known as LIR-2 and LILRB2, is a type I transmembrane protein expressed primarily on monocytes and dendritic cells (DC). LILRB2 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles.
Product Category
 Recombinant Protein
Target
 LILRB2/CD85d/ILT4
Synonyms
 CD85d; ILT4; ILT-4; ILT4CD85d; LILRB2; LIR2; MIR10
Accession
Species
 Cynomolgus
Biotinylated
 no
Amino Acid Range
 Gly24-Arg457
Molecular Weight
 The protein has a predicted MW of 48.2 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Activity
 The affinity constant of 852 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag
 C-His
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Cynomolgus LILRB2, His Tag immobilized on CM5 Chip can bind Cynomolgus HLA-G Complex Tetramer, His Tag with an affinity constant of 852 nM as determined in SPR assay (Biacore T200).
Cynomolgus LILRB2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Cynomolgus LILRB2 is greater than 95% as determined by SEC-HPLC.

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