Product Description |
Recombinant Cynomolgus/Rhesus macaque FOLR1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Arg25-Met233. |
Product Background |
Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. |
Product Category |
Recombinant Protein / Antibody discovery / CAR-T targets |
Protein |
FOLR1 |
Synonyms |
FR-alpha; FR alpha; FR α; FOLR; FOLR1; FBP; Folbp1; KB cells FBP; MOv18; Folate receptor 1; Fbp1; Folate receptor alpha; |
Accession |
|
Species |
Cynomolgus/Rhesus macaque |
Biotinylated |
no |
Amino Acid Range |
Arg25-Met233 |
Molecular Weight |
The protein has a predicted MW of 25.6 kDa. Due to glycosylation, the protein migrates to 35-45 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Cynomolgus/Rhesus macaque FOLR1, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-FOLR1 Antibody, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
-20 to -80°C for 24 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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Immobilized Cynomolgus/Rhesus macaque FOLR1, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-FOLR1 Antibody, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA. |
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Cynomolgus/Rhesus macaque FOLR1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Cynomolgus/Rhesus macaque FOLR1 is greater than 95% as determined by SEC-HPLC. |
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