Name: Cynomolgus TRAIL R2/DR5/TNFRSF10B Protein (TRL-CM1R2)
Brand: KactusBio
SKU: TRL-CM1R2-100UG
Price: 247.5 USD
Availability: InStock

ELISA binding curve of Cynomolgus TRAIL R2 His Tag protein with anti-TRAIL R2 antibody, showing dose-dependent signal at OD450

Cynomolgus TRAIL R2/DR5/TNFRSF10B Protein (TRL-CM1R2)

Immobilized Cynomolgus TRAIL R2, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-TRAIL R2 Antibody, hFc Tag with the EC50 of 3.9ng/ml determined by ELISA.

Cynomolgus TRAIL R2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Cynomolgus TRAIL R2 is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Cynomolgus TRAIL R2, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-TRAIL R2 Antibody, hFc Tag with the EC50 of 3.9ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Ile58-Ser212

Catalog #TRL-CM1R2

Size

100UG

500UG

Order by 4pm ET for delivery on:

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Cynomolgus TRAIL R2/DR5/TNFRSF10B Protein (TRL-CM1R2) Summary

Product Description	Recombinant Cynomolgus TRAIL R2/DR5/TNFRSF10B Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ile58-Ser212.
Product Background	DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Cynomolgus TRAIL R2/DR5/TNFRSF10B Protein (TRL-CM1R2) Specifications/Details

Protein	TRAIL R2/DR5/TNFRSF10B
Synonyms	CD262; DR5; DR5TRICK2B; Fas-like protein; KILLER/DR5; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRICK2; TRICK2A; TRICKB; ZTNFR9; KILLER
Accession	A0A2K5TXK0
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Ile58-Ser212
Molecular Weight	The protein has a predicted MW of 18.28 kDa. Due to glycosylation, the protein migrates to 25-35 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus TRAIL R2, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-TRAIL R2 Antibody, hFc Tag with the EC50 of 3.9ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Immobilized Cynomolgus TRAIL R2, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-TRAIL R2 Antibody, hFc Tag with the EC50 of 3.9ng/ml determined by ELISA.
	Cynomolgus TRAIL R2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Cynomolgus TRAIL R2 is greater than 95% as determined by SEC-HPLC.