Cynomolgus TRAIL R2/DR5/TNFRSF10B Protein (TRL-CM1R2)
Catalog: TRL-CM1R2
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Product Description | Recombinant Cynomolgus TRAIL R2/DR5/TNFRSF10B Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ile58-Ser212. |
Product Background |
DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. |
Product Category |
Recombinant Protein |
Target |
TRAIL R2/DR5/TNFRSF10B |
Accession | |
Species |
Cynomolgus |
Amino Acid Range |
Ile58-Ser212 |
Molecular Weight | The protein has a predicted MW of 18.28 kDa. Due to glycosylation, the protein migrates to 25-35 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Cynomolgus TRAIL R2, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-TRAIL R2 Antibody, hFc Tag with the EC50 of 3.9ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
Endotoxin | Less than 1EU per ug by the LAL method. |
Form | Lyophilized |
Shipping | Shipped at ambient temperature. |
Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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