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FITC-Labeled Human CD47 Protein (CD7-HM147F) Summary
Product Description |
Recombinant FITC-Labeled Human CD47 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Gln19-Pro139. |
Product Background |
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα).CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers. |
Product Category |
Recombinant Protein / Antibody discovery / Immune checkpoint proteins, ADC targets |
FITC-Labeled Human CD47 Protein (CD7-HM147F) Specifications/Details
Protein |
CD47 |
Synonyms |
CD47 glycoprotein; CD47 molecule; CD47; IAP; OA3; MER6 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Gln19-Pro139 |
Molecular Weight |
The protein has a predicted MW of 14.5 kDa. Due to glycosylation, the protein migrates to 45-55 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized FITC-Labeled Human CD47, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human SIRP alpha, hFc Tag with the EC50 of 77.4ng/ml determined by ELISA (QC Test). |
Product Tag |
C-His |
Fluorophore |
FITC-Labeled |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 6 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Immobilized FITC-Labeled Human CD47, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human SIRP alpha, hFc Tag with the EC50 of 77.4ng/ml determined by ELISA (QC Test). |
|
|
FITC-Labeled Human CD47 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of FITC-Labeled Human CD47 is greater than 90% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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