Product Description |
Recombinant Human AXL Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ala26-Pro449. |
Product Background |
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. |
Product Category |
Recombinant Protein |
Target |
Axl |
Synonyms |
Axl; UFO; AXL oncogene; AXL; ARK; JTK11; Tyro7; AI323647; EC 2.7.10; EC 2.7.10.1 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Ala26-Pro449 |
Molecular Weight |
The protein has a predicted MW of 72.6 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human GAS6, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human AXL, hFc Tag with the EC50 of 3.4 ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-hFc |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Immobilized Human GAS6, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human AXL, hFc Tag with the EC50 of 3.4 ng/ml determined by ELISA. |
|
|
Human AXL on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Human AXL is greater than 95% as determined by SEC-HPLC. |
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