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Human CD37 Protein (CD3-HM137) Summary
Product Description |
Recombinant Human CD37 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ala113-Asn240. |
Product Background |
CD37 is a tetraspanin expressed prominently on the surface of B cells. It is an attractive molecular target exploited in the immunotherapy of B cell-derived lymphomas and leukemia. Currently, several monoclonal antibodies targeting CD37 as well as chimeric antigen receptor-based immunotherapies are being developed and investigated in clinical trials. Given the unique role of CD37 in the biology of B cells, it seems that CD37 constitutes more than a docking point for monoclonal antibodies, and targeting this molecule may provide additional benefit to relapsed or refractory patients. |
Product Category |
Recombinant Protein / Antibody discovery / ADC targets |
Human CD37 Protein (CD3-HM137) Specifications/Details
Protein |
CD37 |
Synonyms |
Tetraspanin-26; Tspan-26; CD37; CD37 molecule; GP52-40; MGC120234 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Ala113-Asn240 |
Molecular Weight |
The protein has a predicted MW of 15.72 kDa. Due to glycosylation, the protein migrates to 25-40 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Human CD37 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
Other Available Proteins:
Finding available proteins...
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