Human CD37 Protein (CD3-HM237)

  • Express System: HEK293
  • Product Tag: N-hFc
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Exact Sequence: Ala113-Asn240

Catalog: CD3-HM237

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Product Description Recombinant Human CD37 Protein is expressed from HEK293 with hFc tag at the N-Terminus.It contains Ala113-Asn240.

Product Background

CD37 is a tetraspanin expressed prominently on the surface of B cells. It is an attractive molecular target exploited in the immunotherapy of B cell-derived lymphomas and leukemia. Currently, several monoclonal antibodies targeting CD37 as well as chimeric antigen receptor-based immunotherapies are being developed and investigated in clinical trials. Given the unique role of CD37 in the biology of B cells, it seems that CD37 constitutes more than a docking point for monoclonal antibodies, and targeting this molecule may provide additional benefit to relapsed or refractory patients.

Product Category

Recombinant Protein

Target

CD37
Synonyms Tetraspanin-26; Tspan-26; CD37; CD37 molecule; GP52-40; MGC120234

Gene/Protein ID

P11049-1

Species

Human

Exact Sequence

Ala113-Asn240
Molecular Weight The protein has a predicted MW of 41.9 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.

Product Tag

N-hFc

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Human CD37 is greater than 95% as determined by SEC-HPLC.
Human CD37 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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