Name: Human CD46 Protein (CD4-HM146)
Brand: KactusBio
SKU: CD4-HM146-100UG
Price: 285.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human CD46, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-CD46 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Cys35-Asp343

Catalog #CD4-HM146

Size

100UG

500UG

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Product Description	Recombinant Human CD46 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Cys35-Asp343.
Product Background	CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in preventing complement deposition on host tissue is underpinned by the fact that deficiency of CD46 is a predisposing factor for numerous disease conditions arising from complement-mediated 'self-attack'.
Product Category	Recombinant Protein

Protein	CD46
Synonyms	TLX; CD46; MCP; MIC10; AHUS2; TRA2.10
Accession	P15529-1
Species	Human
Biotinylated	no
Amino Acid Range	Cys35-Asp343
Molecular Weight	The protein has a predicted MW of 35.4 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human CD46, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-CD46 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Human CD46, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-CD46 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA.
	Human CD46 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human CD46 is greater than 95% as determined by SEC-HPLC.

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