Product Description |
Recombinant Human CD46 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Cys35-Asp343. |
Product Background |
CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in preventing complement deposition on host tissue is underpinned by the fact that deficiency of CD46 is a predisposing factor for numerous disease conditions arising from complement-mediated 'self-attack'. |
Product Category |
Recombinant Protein / Antibody discovery |
Protein |
CD46 |
Synonyms |
TLX; CD46; MCP; MIC10; AHUS2; TRA2.10 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Cys35-Asp343 |
Molecular Weight |
The protein has a predicted MW of 35.4 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human CD46, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-CD46 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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|
Immobilized Human CD46, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-CD46 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA. |
|
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Human CD46 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human CD46 is greater than 95% as determined by SEC-HPLC. |
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