Human CD46 Protein (CD4-HM146)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human CD46, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-CD46 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Cys35-Asp343

Catalog: CD4-HM146

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Product Description Recombinant Human CD46 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Cys35-Asp343.

Product Background

CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in preventing complement deposition on host tissue is underpinned by the fact that deficiency of CD46 is a predisposing factor for numerous disease conditions arising from complement-mediated 'self-attack'.

Product Category

Recombinant Protein

Target

CD46
Synonyms TLX; CD46; MCP; MIC10; AHUS2; TRA2.10

Gene/Protein ID

P15529-1

Species

Human

Exact Sequence

Cys35-Asp343
Molecular Weight The protein has a predicted MW of 35.4 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Human CD46, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-CD46 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human CD46, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-CD46 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA.
The purity of Human CD46 is greater than 95% as determined by SEC-HPLC.
Human CD46 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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