Name: Human CD96/TACTILE Protein (CD9-HM396)
Brand: KactusBio
SKU: CD9-HM396-100UG
Price: 346.5 USD
Availability: InStock

Express System: HEK293
Product Tag: C-mFc
Purity: > 95% as determined by Bis-Tris PAGE
Activity: Immobilized Human CD96, mFc Tag at 5ug/ml (100ul/Well) on the plate. Dose response curve for Human CD155, hFc Tag with the EC50 of 0.19ug/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Val22-Met503

Catalog #CD9-HM396

Size

100UG

500UG

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Product Description	Recombinant Human CD96/TACTILE Protein is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus.It contains Val22-Met503.
Product Background	The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cell activity in mice, with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance. The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor, CD226, offers unique strategies for immuno-oncology drug development.
Product Category	Recombinant Protein / Antibody discovery / Immune checkpoint proteins

Protein	CD96/TACTILE
Synonyms	CD96 molecule; CD96; DKFZp667E2122; TACTILE
Accession	P40200-2
Species	Human
Biotinylated	no
Amino Acid Range	Val22-Met503
Molecular Weight	The protein has a predicted MW of 79.8 kDa. Due to glycosylation, the protein migrates to 120-160 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human CD96, mFc Tag at 5ug/ml (100ul/Well) on the plate. Dose response curve for Human CD155, hFc Tag with the EC50 of 0.19ug/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-mFc
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human CD96, mFc Tag at 5ug/ml (100ul/Well) on the plate. Dose response curve for Human CD155, hFc Tag with the EC50 of 0.19ug/ml determined by ELISA (QC Test).
	Immobilized Human CD96, mFc Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Anti-CD96 Antibody, hFc Tag with the EC50 of 31.8ng/ml determined by ELISA.
	Human CD96 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.