Human CDH17/Cadherin 17 Domain 1&2 Protein (CDH-HM1D5)
Human CDH17/Cadherin 17 Domain 1&2 Protein (CDH-HM1D5)
Human CDH17/Cadherin 17 Domain 1&2 Protein (CDH-HM1D5)
Human CDH17/Cadherin 17 Domain 1&2 Protein (CDH-HM1D5)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE
  • Activity: Immobilized Human CDH17 Domain 1&2, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 4.7ng/ml determined by ELISA (QC Test). See testing image for detail.
  • Amino Acid Range: Pro30-Pro244
Catalog #CDH-HM1D5
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Product Description
 Recombinant Human CDH17/Cadherin 17 Domain 1&2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Pro30-Pro244.
Product Background
 Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Product Category
 Recombinant Protein
Target
 CDH17/Cadherin 17 Domain 1&2
Synonyms
 Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16;
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Pro30-Pro244
Molecular Weight
 The protein has a predicted MW of 25.15 kDa. Due to glycosylation, the protein migrates to 35-45 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Human CDH17 Domain 1&2, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 4.7ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag
 C-His
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human CDH17 Domain 1&2, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 4.7ng/ml determined by ELISA (QC Test).
Human CDH17 Domain 1&2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

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