Human CDH17/Cadherin 17 Domain 1&2 Protein (CDH-HM1D5)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE
  • Activity: Immobilized Human CDH17 Domain 1&2, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 11.4ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Pro30-Pro244

Catalog: CDH-HM1D5

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Product Description Recombinant Human CDH17/Cadherin 17 Domain 1&2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Pro30-Pro244.

Product Background

 Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Product Category

 Recombinant Protein

Target

 CDH17/Cadherin 17 Domain 1&2

Gene/Protein ID

 Q12864

Species

 Human

Exact Sequence

 Pro30-Pro244
Molecular Weight The protein has a predicted MW of 25.15 kDa. Due to glycosylation, the protein migrates to 35-45 kDa based on Tris-Bis PAGE result.

Activity

 Immobilized Human CDH17 Domain 1&2, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 11.4ng/ml determined by ELISA. See testing image for detail.

Product Tag

 C-His

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human CDH17 Domain 1&2, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 11.4ng/ml determined by ELISA.
Human CDH17 Domain 1&2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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