Human CDH17/Cadherin 17 Protein (CDH-HM217)
Human CDH17/Cadherin 17 Protein (CDH-HM217)
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human CDH17, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Antibody, hFc Tag with the EC50 of 8.6ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Gln23-Met787
Catalog #CDH-HM217
Regular price $300.00
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Product Description

Recombinant Human CDH17/Cadherin 17 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Gln23-Met787.

Product Background

Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Product Category

Recombinant Protein / Antibody discovery

Protein

CDH17/Cadherin 17

Synonyms

Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16; FLJ26931; MGC138218; MGC142024

Accession

Species

Human

Biotinylated

no

Amino Acid Range

Gln23-Met787

Molecular Weight

The protein has a predicted MW of 111.73 kDa. Due to glycosylation, the protein migrates to 113-135 kDa based on Bis-Tris PAGE result.

Activity

Immobilized Human CDH17, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Antibody, hFc Tag with the EC50 of 8.6ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-hFc

Expression System

HEK293

Purity

> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC

Endotoxin

Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Human CDH17, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Antibody, hFc Tag with the EC50 of 8.6ng/ml determined by ELISA. Immobilized Human CDH17, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Antibody, hFc Tag with the EC50 of 8.6ng/ml determined by ELISA.
Human CDH17 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human CDH17 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human CDH17 is greater than 95% as determined by SEC-HPLC. The purity of Human CDH17 is greater than 95% as determined by SEC-HPLC.

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