Name: Human CDH17/Cadherin 17 Protein (CDH-HM217)
Brand: KactusBio
SKU: CDH-HM217-100UG
Price: 330.0 USD
Availability: InStock

Human CDH17/Cadherin 17 Protein (CDH-HM217)

Immobilized Human CDH17, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Antibody, hFc Tag with the EC50 of 15.1ng/ml determined by ELISA.

Human CDH17 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Loaded Biotinylated Anti-CDH17 Antibody, hFc-Avi Tag on Streptavidin-Biosensor can bind Human CDH17, hFc Tag with an affinity constant of 0.14 nM as determined in BLI assay (Gator® Prime).

The purity of Human CDH17 is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-hFc (IgG1)
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human CDH17, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Antibody, hFc Tag with the EC50 of 15.1ng/ml determined by ELISA.
Amino Acid Range: Gln23-Met787

Catalog #CDH-HM217

Size

100UG

500UG

Order by 4pm ET for delivery on:

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Human CDH17/Cadherin 17 Protein (CDH-HM217) Summary

Product Description	Recombinant Human CDH17/Cadherin 17 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Gln23-Met787.
Product Background	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Product Category	Recombinant Protein / Antibody discovery / ADC targets

Human CDH17/Cadherin 17 Protein (CDH-HM217) Specifications/Details

Protein	CDH17/Cadherin 17
Synonyms	Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16; FLJ26931; MGC138218; MGC142024
Accession	Q12864
Species	Human
Biotinylated	no
Amino Acid Range	Gln23-Met787
Molecular Weight	The protein has a predicted MW of 111.73 kDa. Due to glycosylation, the protein migrates to 113-135 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human CDH17, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Antibody, hFc Tag with the EC50 of 15.1ng/ml determined by ELISA.
Product Tag	C-hFc (IgG1)
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Immobilized Human CDH17, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Antibody, hFc Tag with the EC50 of 15.1ng/ml determined by ELISA.
	Human CDH17 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	Loaded Biotinylated Anti-CDH17 Antibody, hFc-Avi Tag on Streptavidin-Biosensor can bind Human CDH17, hFc Tag with an affinity constant of 0.14 nM as determined in BLI assay (Gator® Prime).
	The purity of Human CDH17 is greater than 95% as determined by SEC-HPLC.