Product Description |
Recombinant Human CEACAM-5/CD66e (145-322) Protein is expressed from HEK293 with His tag at the C-terminus; It contains Pro145-Pro322. |
Product Background |
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver. CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites. Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors, and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated. |
Product Category |
Recombinant Protein |
Target |
CEACAM-5/CD66e (145-322) |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Pro145-Pro322 |
Molecular Weight |
The protein has a predicted MW of 20.66 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
>95% as determined by Bis-Tris PAGE; >95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Human CEACAM-5 (145-322) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human CEACAM-5 (145-322) is greater than 95% as determined by SEC-HPLC. |
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