Human DSG-2/Desmoglein-2 Protein (DSG-HM102)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE
  • Activity: Immobilized Human DSG-2, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-DSG-2 Antibody, hFc Tag with the EC50 of 18.2ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Ala50-Gly609

Catalog: DSG-HM102

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Product Description Recombinant Human DSG-2/Desmoglein-2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ala50-Gly609.

Product Background

Desmoglein-2 (DSG-2) as the primary high-affinity receptor used by adenoviruses Ad3, Ad7, Ad11 and Ad14. These serotypes represent key human pathogens causing respiratory and urinary tract infections. In epithelial cells, adenovirus binding of DSG-2 triggers events reminiscent of epithelial-to-mesenchymal transition, leading to transient opening of intercellular junctions.

Product Category

Recombinant Protein

Target

DSG-2/Desmoglein-2
Synonyms Desmoglein-2; HDGC; DSG2; CDHF5; ARVC10; CMD1BB; MGC117036; MGC117037
Accession

Species

Human

Amino Acid Range

Ala50-Gly609
Molecular Weight The protein has a predicted MW of 63.6 kDa. Due to glycosylation, the protein migrates to 75-80 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Human DSG-2, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-DSG-2 Antibody, hFc Tag with the EC50 of 18.2ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human DSG-2, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-DSG-2 Antibody, hFc Tag with the EC50 of 18.2ng/ml determined by ELISA.
Human DSG-2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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