Human FOLR1 Protein (FOL-HM4R1)

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: Immobilized Human FOLR1, His Tag at 0.5ug/ml (100ul/Well) on plate.Dose response curve for Anti-FOLR1 Antibody, hFc Tag with the EC50 of 18.6ng/ml determined by ELISA. See testing image for detail.
Exact Sequence: Arg25-Met233

Catalog: FOL-HM4R1

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Product Description	Recombinant Human FOLR1 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Arg25-Met233.
Product Background	Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH.
Product Category	Recombinant Protein

Target	FOLR1
Synonyms	FOLR; FOLR1; FBP; Folbp1; KB cells FBP; MOv18
Gene/Protein ID	P15328
Species	Human
Exact Sequence	Arg25-Met233
Molecular Weight	The protein has a predicted MW of 27.5 kDa. Due to glycosylation, the protein migrates to 38-45 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Human FOLR1, His Tag at 0.5ug/ml (100ul/Well) on plate.Dose response curve for Anti-FOLR1 Antibody, hFc Tag with the EC50 of 18.6ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His-Avi
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Human FOLR1, His Tag at 0.5ug/ml (100ul/Well) on plate.Dose response curve for Anti-FOLR1 Antibody, hFc Tag with the EC50 of 18.6ng/ml determined by ELISA.
	The purity of Human FOLR1 is greater than 95% as determined by SEC-HPLC.
	Human FOLR1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.