Human GUCY2C/Guanylyl cyclase C Protein (GCC-HM201)

  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human GUCY2C, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-GUCY2C Antibody, hFc Tag with the EC50 of 25.6ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Ser24-Gln430

Catalog: GCC-HM201

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Product Description Recombinant Human GUCY2C/Guanylyl cyclase C Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ser24-Gln430.

Product Background

 Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy.

Product Category

 Recombinant Protein

Target

 GUCY2C/Guanylyl cyclase C
Synonyms Guanylyl cyclase C; GC-C; STAR; GUCY2C; GUC2C; STA receptor; DIAR6; EC 4.6.1; GCC; GUC2CEC 4.6.1.2; MUCIL

Gene/Protein ID

 P25092-1

Species

 Human

Exact Sequence

 Ser24-Gln430
Molecular Weight The protein has a predicted MW of 72.8 kDa. Due to glycosylation, the protein migrates to 85-115 kDa based on Tris-Bis PAGE result.

Activity

 Immobilized Human GUCY2C, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-GUCY2C Antibody, hFc Tag with the EC50 of 25.6ng/ml determined by ELISA. See testing image for detail.

Product Tag

 C-hFc

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human GUCY2C, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-GUCY2C Antibody, hFc Tag with the EC50 of 25.6ng/ml determined by ELISA.
The purity of Human GUCY2C is greater than 95% as determined by SEC-HPLC.
Human GUCY2C on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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