Human GUCY2C/Guanylyl cyclase C Protein (GCC-HM201)
Human GUCY2C/Guanylyl cyclase C Protein (GCC-HM201)
Human GUCY2C/Guanylyl cyclase C Protein (GCC-HM201)
Human GUCY2C/Guanylyl cyclase C Protein (GCC-HM201)
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human GUCY2C, hFc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-GUCY2C Antibody, hFc Tag with the EC50 of 16.2ng/ml determined by ELISA (QC Test). See testing image for detail.
  • Amino Acid Range: Ser24-Gln430
Catalog #GCC-HM201
Regular price $315.00
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Product Description
Recombinant Human GUCY2C/Guanylyl cyclase C Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ser24-Gln430.
Product Background
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy.
Product Category
Recombinant Protein
Target
GUCY2C/Guanylyl cyclase C
Synonyms
Guanylyl cyclase C; GC-C; STAR; GUCY2C; GUC2C; STA receptor; DIAR6; EC 4.6.1; GCC; GUC2CEC 4.6.1.2; MUCIL
Accession
Species
Human
Biotinylated
no
Amino Acid Range
Ser24-Gln430
Molecular Weight
The protein has a predicted MW of 72.8 kDa. Due to glycosylation, the protein migrates to 85-115 kDa based on Bis-Tris PAGE result.
Activity
Immobilized Human GUCY2C, hFc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-GUCY2C Antibody, hFc Tag with the EC50 of 16.2ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag
C-hFc
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human GUCY2C, hFc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-GUCY2C Antibody, hFc Tag with the EC50 of 16.2ng/ml determined by ELISA (QC Test).
Human GUCY2C on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human GUCY2C is greater than 95% as determined by SEC-HPLC.

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