Human Her2/ErbB2 (S310F) Protein (HER-HM112)
Human Her2/ErbB2 (S310F) Protein (HER-HM112)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
  • Activity: Immobilized Human Her2 (S310F), His Tag at 1ug/ml (100 ul/well) on the plate. Dose response curve for Anti-HER2 Antibody, hFc Tag with the EC50 of 2.7ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Thr23-Thr652 (S310F)
Catalog #HER-HM112
Regular price $330.00
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Product Description

Recombinant Human Her2/ErbB2 (S310F) Protein is expressed from HEK293 with His tag at the C-terminus.; It contains Thr23-Thr652 (S310F).

Product Background

ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors.Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane.

Product Category

Recombinant Protein / Antibody discovery / CAR-T targets

Protein

Her2/ErbB2 (S310F)

Synonyms

CD340; EGFR2; ErbB2; HER2; HER-2; herstatin; MLN 19; MLN19; NGL; TKR1; ERBB2; NEU; ENV; ENVW; ERVWE1; HERV7Q; HERVW

Accession

Species

Human

Biotinylated

no

Amino Acid Range

Thr23-Thr652 (S310F)

Molecular Weight

The protein has a predicted MW of 70.50 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Bis-Tris PAGE result.

Activity

Immobilized Human Her2 (S310F), His Tag at 1ug/ml (100 ul/well) on the plate. Dose response curve for Anti-HER2 Antibody, hFc Tag with the EC50 of 2.7ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-His

Expression System

HEK293

Purity

>95% as determined by Bis-Tris PAGE;>95% as determined by HPLC

Endotoxin

Less than 1 EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Human Her2 (S310F), His Tag at 1ug/ml (100 ul/well) on the plate. Dose response curve for Anti-HER2 Antibody, hFc Tag with the EC50 of 2.7ng/ml determined by ELISA. Immobilized Human Her2 (S310F), His Tag at 1ug/ml (100 ul/well) on the plate. Dose response curve for Anti-HER2 Antibody, hFc Tag with the EC50 of 2.7ng/ml determined by ELISA.
Human Her2 (S310F) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human Her2 (S310F) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human Her2 (S310F) is greater than 95% as determined by SEC-HPLC. The purity of Human Her2 (S310F) is greater than 95% as determined by SEC-HPLC.

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