Product Description |
Recombinant Human Integrin alpha 2 beta 1(ITGA2&ITGB1) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Tyr30-T1132(ITGA2) acidic tail & Gln21-Asp728(ITGB1) basic tail. |
Product Background |
The α2β1 integrin, also known as VLA-2, GPIa-IIa, CD49b, was first identified as an extracellular matrix receptor for collagens and/or laminins. It is now recognized that the α2β1 integrin serves as a receptor for many matrix and nonmatrix molecules. It plays a critical role in platelet function and homeostasis. |
Product Category |
Recombinant Protein |
Protein |
Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer |
Synonyms |
α2β1; Integrin alpha A1 beta 1; alpha A1 beta 1; alpha A1; beta 1; ITGA1&ITGB1; ITGA&ITGB; VLA-2, GPIa-IIa, CD49b;Integrin alpha A1 β 1; alpha A1 β 1; β 1 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Tyr30-T1132(ITGA2) acidic tail & Gln21-Asp728(ITGB1) basic tail |
Molecular Weight |
The protein has a predicted MW of 126.6 kDa(ITGA2)&83.2 kDa(ITGB1). Due to glycosylation, the protein migrates to 110-140 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Human ITGA2&ITGB1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human ITGA2&ITGB1 is greater than 95% as determined by SEC-HPLC. |
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