Human Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer Protein (ITG-HM461)
Catalog: ITG-HM461
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| Product Description | Recombinant Human Integrin alpha 6 beta 1 (ITGA6&ITGB1) Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Phe24-Gly1012(ITGA6) acidic tail and GIn21-Asp728(ITGB1) basic tail. |
Product Background |
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling |
Product Category |
Recombinant Protein |
Target |
Integrin ITGA6&ITGB1 Heterodimer |
| Synonyms | Integrin alpha 6 beta 1; ITGA6&ITGB1 |
Gene/Protein ID |
P23229-2(ITGA6)&P05556-1(ITGB1) |
Species |
Human |
Exact Sequence |
Phe24-Gly1012(ITGA6) acidic tail & GIn21-Asp728(ITGB1) basic tail |
| Molecular Weight | The protein has a predicted MW of 117.9 kDa (ITGA6) and 83.2 kDa (ITGB1). Due to glycosylation, the protein migrates to 140-160 kDa (ITGA6) and 110-150 kDa (ITGB1) under Non reducing (N) condition based on Tris-Bis PAGE result. |
Product Tag |
C-His-Avi |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Liquid |
| Shipping | Shipped with dry ice. |
| Formulation | Supplied as 0.22um filtered solution in PBS (pH 7.4). |
| Stability And Storage | Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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Human ITGA6&ITGB1 on Tris-Bis PAGE under Non reducing (N) condition. The purity is greater than 95%. |
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