Human Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer Protein (ITG-HM461)

Human ITGA6&ITGB1 on Bis-Tris PAGE under Non reducing (N) condition. The purity is greater than 95%.

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE
Amino Acid Range: Phe24-Gly1012 (ITGA6) acidic tail & GIn21-Asp728 (ITGB1) basic tail

Catalog #ITG-HM461

Size

100UG

500UG

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Product Description	Recombinant Human Integrin alpha 6 beta 1 (ITGA6&ITGB1) Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Phe24-Gly1012 (ITGA6) acidic tail and GIn21-Asp728 (ITGB1) basic tail.
Product Background	Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling
Product Category	Recombinant Protein / Antibody discovery

Protein	Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer
Synonyms	α6β1; Integrin alpha 6 beta 1; ITGA6&ITGB1;Integrin alpha 6 β 1
Accession	P23229-2 (ITGA6) & P05556-1 (ITGB1)
Species	Human
Biotinylated	no
Amino Acid Range	Phe24-Gly1012 (ITGA6) acidic tail & GIn21-Asp728 (ITGB1) basic tail
Molecular Weight	The protein has a predicted MW of 117.9 kDa (ITGA6) and 83.2 kDa (ITGB1). Due to glycosylation, the protein migrates to 140-160 kDa (ITGA6) and 110-150 kDa (ITGB1) under Non reducing (N) condition based on Bis-Tris PAGE result.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.