Name: Human Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer Protein (ITG-HM1A1)
Brand: KactusBio
SKU: ITG-HM1A1-100UG
Price: 375.0 USD
Availability: InStock

Human Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer Protein (ITG-HM1A1)

Human ITGA1&ITGB1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE
Amino Acid Range: Phe29-Pro1141(ITGA1) acidic tail & Gln21-Asp728(ITGB1) basic tail

Catalog #ITG-HM1A1

Size

100UG

500UG

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Product Description	Recombinant Human Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe29-Pro1141(ITGA1) acidic tail & Gln21-Asp728(ITGB1) basic tail.
Product Background	Integrin α1β1 is a heterodimer of the Integrin subunits alpha 1 and beta 1 and is one of four collagen‑binding integrins, it preferentially binds Collagens I, IV, VI, XIII and XVI, but also binds Laminin. Integrin α1β1 is widely expressed in mesenchyme and the immune system, as well as a minority of epithelial tissues. It can suppresse EGFR signaling, increase expression of Caveolin-1, reduce production of reactive oxygen species, regulate collagen expression, regulate MMP collagenase and gelatinase activity, and mediates the renal basement membrane disorder Alport syndrome.
Product Category	Recombinant Protein / Antibody discovery

Protein	Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer
Synonyms	Integrin alpha 1 beta 1; alpha 1 beta 1; alpha 1; beta 1; ITGA1&ITGB1; ITGA&ITGB;Integrin alpha 1 β 1; alpha 1 β 1; β 1
Accession	P56199-1(ITGA1)&P05556-1(ITGB1)
Species	Human
Biotinylated	no
Amino Acid Range	Phe29-Pro1141(ITGA1) acidic tail & Gln21-Asp728(ITGB1) basic tail
Molecular Weight	The protein has a predicted MW of 129.1 kDa(ITGA1)&83.2 kDa(ITGB1). Due to glycosylation, the protein migrates to 160-200 kDa based on Bis-Tris PAGE result.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in 50mM Tris, 150mM NaCl (pH 7.5). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.