Name: Human Noggin Protein (NOG-HM001)
Brand: KactusBio
SKU: NOG-HM001-100UG
Price: 270.0 USD
Availability: InStock

Catalog #NOG-HM001

Size

100UG

500UG

Order now, ships by:

Product Description	Recombinant Human Noggin Protein is expressed from CHO without tag.It contains Gln28-Cys232.
Product Background	Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer Genome Atlas human GC cohort. Targeting EGFR and its downstream pathways diminished cell proliferation which was promoted by Noggin. Noggin promotes the proliferation of GC cells by upregulating EGFR and enhancing a vicious circle formed by β‑catenin, EGFR, ERK and Akt.
Product Category	Recombinant Protein / Antibody discovery

Protein	Noggin
Synonyms	Noggin; NOG; SYM1; SYNS1
Accession	Q13253
Species	Human
Biotinylated	no
Amino Acid Range	Gln28-Cys232
Molecular Weight	The protein has a predicted MW of 23.05 kDa. Due to glycosylation, the protein migrates to 30-36 kDa based on Bis-Tris PAGE result.
Product Tag	No Tag
Expression System	CHO
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 0.05EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human Noggin on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50-for this effect is-4-80 ng/mL in the presence of 50 ng/mL of recombinant Human BMP‑4.
	The purity of Human Noggin is greater than 95% as determined by SEC-HPLC.