Human Siglec-2/CD22 Protein (SIG-HM122)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE
  • Activity: Immobilized Human Siglec-2, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-Siglec-2 Antibody, hFc Tag with the EC50 of 6.6ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Asp20-Arg687

Catalog: SIG-HM122

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Product Description Recombinant Human Siglec-2/CD22 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asp20-Arg687.

Product Background

CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.

Product Category

Recombinant Protein

Target

Siglec-2/CD22
Synonyms CD22 molecule; CD22; Siglec-2; B-cell receptor CD22; BL-CAM; SIGLEC2; SIGLEC2FLJ22814
Accession

Species

Human

Amino Acid Range

Asp20-Arg687
Molecular Weight The protein has a predicted MW of 76.2 kDa. Due to glycosylation, the protein migrates to 100-120 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Human Siglec-2, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-Siglec-2 Antibody, hFc Tag with the EC50 of 6.6ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human Siglec-2, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-Siglec-2 Antibody, hFc Tag with the EC50 of 6.6ng/ml determined by ELISA.
Human Siglec-2/CD22 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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