Human Siglec-2/CD22 Protein (SIG-HM222)
Catalog: SIG-HM222
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Product Description | Recombinant Human Siglec-2/CD22 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Asp20-Arg687. |
Product Background |
CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice. |
Product Category |
Recombinant Protein |
Target |
Siglec2/CD22 |
Synonyms | CD22 molecule; CD22; Siglec-2; B-cell receptor CD22; BL-CAM; SIGLEC2; SIGLEC2FLJ22814 |
Gene/Protein ID |
P20273-1 |
Species |
Human |
Exact Sequence |
Asp20-Arg687 |
Molecular Weight | The protein has a predicted MW of 101.9 kDa. Due to glycosylation, the protein migrates to 120-130 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Human Siglec-2, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-Siglec-2 Antibody, hFc Tag with the EC50 of 18.4ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-hFc |
Express System |
HEK293 |
Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
Endotoxin | Less than 1EU per ug by the LAL method. |
Form | Lyophilized |
Shipping | Shipped at ambient temperature. |
Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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