Human TRAIL R2/DR5/TNFRSF10B Protein (DR5-HM201)
Human TRAIL R2/DR5/TNFRSF10B Protein (DR5-HM201)
Human TRAIL R2/DR5/TNFRSF10B Protein (DR5-HM201)
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human Trail, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human TRAIL R2, hFc Tag with the EC50 of 9.8ng/ml determined by ELISA (QC Test). See testing image for detail.
  • Amino Acid Range: Ile56-Glu182
Catalog #DR5-HM201
Regular price $247.50
/
Size

Order now, ships by:

Product Description

Recombinant Human TRAIL R2/DR5/TNFRSF10B Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ile56-Glu182.

Product Background

DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

Product Category

Recombinant Protein / Antibody discovery / Antibody discovery | Others

Protein

TRAIL R2/DR5/TNFRSF10B

Synonyms

CD262; DR5; DR5TRICK2B; Fas-like protein; KILLER/DR5; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRICK2; TRICK2A; TRICKB; ZTNFR9; KILLER

Accession

Species

Human

Biotinylated

no

Amino Acid Range

Ile56-Glu182

Molecular Weight

The protein has a predicted MW of 41.1 kDa. Due to glycosylation, the protein migrates to 50-55 kDa based on Bis-Tris PAGE result.

Activity

Immobilized Human Trail, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human TRAIL R2, hFc Tag with the EC50 of 9.8ng/ml determined by ELISA (QC Test). See testing image for detail.

Product Tag

C-hFc

Expression System

HEK293

Purity

> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC

Endotoxin

Less than 1 EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in 50mM Tris, 100mM NaCl (pH 7.5). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Human Trail, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human TRAIL R2, hFc Tag with the EC50 of 9.8ng/ml determined by ELISA (QC Test). Immobilized Human Trail, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human TRAIL R2, hFc Tag with the EC50 of 9.8ng/ml determined by ELISA (QC Test).
Human TRAIL R2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human TRAIL R2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human TRAIL R2 is greater than 95% as determined by SEC-HPLC. The purity of Human TRAIL R2 is greater than 95% as determined by SEC-HPLC.

Have more questions?

Check out our Frequently Asked Questions page for more details about product specifications, ordering, and shipments.

Contact Us

support@kactusbio.us

Recently viewed