Human TRAIL/TNFRSF10 Protein (TRL-HE001)

  • Express System: E.coli
  • Product Tag: No Tag
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by SEC-HPLC
  • Activity: Immobilized Human TRAIL at 2ug/ml (100ul/well) on the plate. Dose response curve for Human TRAIL R1, hFc Tag with the EC50 of 25.4ng/ml determined by ELISA (QC Test). The affinity constant of 0.57 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Exact Sequence: Val114-Gly281

Catalog: TRL-HE001

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Product Description Recombinant Human TRAIL/TNFRSF10 Protein is expressed from E.coli without tag.It contains Val114-Gly281.

Product Background

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by binding to its associated death receptors DR4 and DR5. The activation of the TRAIL pathway in inducing tumor-selective apoptosis leads to the development of TRAIL-based cancer therapies, which include recombinant forms of TRAIL, TRAIL receptor agonists, and other therapeutic agents.

Product Category

Recombinant Protein

Target

TRAIL/TNFRSF10
Synonyms Apo-2L; TRAIL; CD253; TNFSF10; Apo-2 ligand; APO2L; TL2

Gene/Protein ID

NP_003801.1

Species

Human

Exact Sequence

Val114-Gly281
Molecular Weight The protein has a predicted MW of 19.6 kDa same as Tris-Bis PAGE result.

Activity

Immobilized Human TRAIL at 2ug/ml (100ul/well) on the plate. Dose response curve for Human TRAIL R1, hFc Tag with the EC50 of 25.4ng/ml determined by ELISA (QC Test). The affinity constant of 0.57 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

No Tag

Express System

E.coli
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by SEC-HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22um filtered solution in 50mM Tris, 300mM NaCl (pH 7.2).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human DcR1, His Tag immobilized on CM5 Chip can bind Human TRAIL, No Tag with an affinity constant of 0.57 nM as determined in SPR assay (Biacore T200).
Immobilized Human TRAIL at 2ug/ml (100ul/well) on the plate. Dose response curve for Human TRAIL R1, hFc Tag with the EC50 of 25.4ng/ml determined by ELISA (QC Test).
The purity of Human TRAIL is greater than 95% as determined by SEC-HPLC.
Human TRAIL on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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