Human TRAIL/TNFRSF10 Protein (TRL-HE001)
Catalog: TRL-HE001
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Product Description | Recombinant Human TRAIL/TNFRSF10 Protein is expressed from E.coli without tag.It contains Val114-Gly281. |
Product Background |
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by binding to its associated death receptors DR4 and DR5. The activation of the TRAIL pathway in inducing tumor-selective apoptosis leads to the development of TRAIL-based cancer therapies, which include recombinant forms of TRAIL, TRAIL receptor agonists, and other therapeutic agents. |
Product Category |
Recombinant Protein |
Target |
TRAIL/TNFRSF10 |
Synonyms | Apo-2L; TRAIL; CD253; TNFSF10; Apo-2 ligand; APO2L; TL2 |
Gene/Protein ID |
NP_003801.1 |
Species |
Human |
Exact Sequence |
Val114-Gly281 |
Molecular Weight | The protein has a predicted MW of 19.6 kDa same as Tris-Bis PAGE result. |
Activity |
Immobilized Human TRAIL at 2ug/ml (100ul/well) on the plate. Dose response curve for Human TRAIL R1, hFc Tag with the EC50 of 25.4ng/ml determined by ELISA (QC Test). The affinity constant of 0.57 nM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
No Tag |
Express System |
E.coli |
Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by SEC-HPLC |
Endotoxin | Less than 1EU per ug by the LAL method. |
Form | Liquid |
Shipping | Shipped with dry ice. |
Formulation | Supplied as 0.22um filtered solution in 50mM Tris, 300mM NaCl (pH 7.2). |
Stability And Storage | Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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