Mouse B7-H3/CD276 Protein (BH7-MM173)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Exact Sequence: Val29-Ala248

Catalog: BH7-MM173

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Product Description Recombinant Mouse B7-H3/CD276 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val29-Ala248.

Product Background

B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction.

Product Category

Recombinant Protein

Target

B7-H3/CD276
Accession

Species

Mouse

Exact Sequence

Val29-Ala248
Molecular Weight The protein has a predicted MW of 24.98 kDa. Due to glycosylation, the protein migrates to 42-52 kDa based on Tris-Bis PAGE result.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Mouse B7-H3 is greater than 95% as determined by SEC-HPLC.
Mouse B7-H3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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