Mouse IGF1R/CD221 Protein (IGF-MM41R)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Tris-Bis PAGE
Activity: Immobilized Mouse IGF1R, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human IGFI, hFc Tag with the EC50 of 2.3ug/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Glu31-His936

Catalog: IGF-MM41R

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Product Description	Recombinant Mouse IGF1R/CD221 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu31-His936.
Product Background	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.
Product Category	Recombinant Protein

Target	IGF1R/CD221
Accession	Q60751
Species	Mouse
Amino Acid Range	Glu31-His936
Molecular Weight	The protein has a predicted MW of 80.72 kDa (alpha subunit) and 23.0 kDa (beta subunit). Due to furin cleavage and glycosylation, the protein migrates to 110-140 kDa(alpha subunit) and 50-65 kDa(beta subunit) based on Tris-Bis PAGE result.
Activity	Immobilized Mouse IGF1R, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human IGFI, hFc Tag with the EC50 of 2.3ug/ml determined by ELISA. See testing image for detail.
Product Tag	C-His
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Mouse IGF1R, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human IGFI, hFc Tag with the EC50 of 2.3ug/ml determined by ELISA.
	Mouse IGF1R on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.