Mouse IGF1R/CD221 Protein (IGF-MM41R)
Mouse IGF1R/CD221 Protein (IGF-MM41R)
Mouse IGF1R/CD221 Protein (IGF-MM41R)
Mouse IGF1R/CD221 Protein (IGF-MM41R)
Mouse IGF1R/CD221 Protein (IGF-MM41R)
Mouse IGF1R/CD221 Protein (IGF-MM41R)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE
  • Activity: Immobilized Mouse IGF1R, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IGFI, hFc Tag with the EC50 of 1.14ug/ml determined by ELISA (QC Test). See testing image for detail.
  • Amino Acid Range: Glu31-His936
Catalog #IGF-MM41R
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Product Description
 Recombinant Mouse IGF1R/CD221 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu31-His936.
Product Background
 The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.
Product Category
 Recombinant Protein
Target
 IGF1R/CD221
Accession
Species
 Mouse
Biotinylated
 no
Amino Acid Range
 Glu31-His936
Molecular Weight
 The protein has a predicted MW of 80.72 kDa (alpha subunit) and 23.0 kDa (beta subunit). Due to furin cleavage and glycosylation, the protein migrates to 110-140 kDa(alpha subunit) and 50-65 kDa(beta subunit) based on Bis-Tris PAGE result.
Activity
 Immobilized Mouse IGF1R, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IGFI, hFc Tag with the EC50 of 1.14ug/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag
 C-His
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Mouse IGF1R, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IGFI, hFc Tag with the EC50 of 1.14ug/ml determined by ELISA (QC Test).
Mouse IGF1R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
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