Name: Mouse IGF1R/CD221 Protein (IGF-MM41R)
Brand: KactusBio
SKU: IGF-MM41R-100UG
Price: 346.5 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Activity: Immobilized Mouse IGF1R, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IGFI, hFc Tag with the EC50 of 1.14ug/ml determined by ELISA (QC Test).
Amino Acid Range: Glu31-His936

Catalog #IGF-MM41R

Size

100UG

500UG

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Mouse IGF1R/CD221 Protein (IGF-MM41R) Summary

Product Description	Recombinant Mouse IGF1R/CD221 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu31-His936.
Product Background	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.
Product Category	Recombinant Protein / Antibody discovery / ADC targets

Mouse IGF1R/CD221 Protein (IGF-MM41R) Specifications/Details

Protein	IGF1R/CD221
Synonyms	CD221; IGF1R; IGF-1R; IGF-I R; IGF-I receptor; IGFIR; IGFR; JTK13; MGC142170; MGC142172; MGC18216
Accession	Q60751
Species	Mouse
Biotinylated	no
Amino Acid Range	Glu31-His936
Molecular Weight	The protein has a predicted MW of 80.72 kDa (alpha subunit) and 23.0 kDa (beta subunit). Due to the furin cleavage site and glycosylation, the protein migrates to 110-140 kDa and 50-65 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Mouse IGF1R, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IGFI, hFc Tag with the EC50 of 1.14ug/ml determined by ELISA (QC Test).
Product Tag	C-His
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Endotoxin	Less than 0.1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Mouse IGF1R, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IGFI, hFc Tag with the EC50 of 1.14ug/ml determined by ELISA (QC Test).
	Mouse IGF1R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Mouse IGF1R is greater than 90% as determined by SEC-HPLC.

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