Mouse LAG3/CD223 Protein (LAG-MM131)
Mouse LAG3/CD223 Protein (LAG-MM131)
Mouse LAG3/CD223 Protein (LAG-MM131)
Mouse LAG3/CD223 Protein (LAG-MM131)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE
  • Activity: Immobilized Mouse LAG3, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Mouse FGL1, hFc Tag with the EC50 of 0.18ug/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Ser23-Leu442
Catalog #LAG-MM131
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Product Description
 Recombinant Mouse LAG3/CD223 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser23-Leu442.
Product Background
 LAG-3, is a protein which in humans is encoded by the LAG3 gene, which is a cell surface molecule with diverse biologic effects on T cell function. It is an immune checkpoint receptor and as such is the target of various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders.
Product Category
 Recombinant Protein
Target
 LAG3/CD223
Synonyms
 CD223; FDC; LAG3; LAG-3; sLAG-3
Accession
Species
 Mouse
Biotinylated
 no
Amino Acid Range
 Ser23-Leu442
Molecular Weight
 The protein has a predicted MW of 46.2 kDa. Due to glycosylation, the protein migrates to 65-70 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Mouse LAG3, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Mouse FGL1, hFc Tag with the EC50 of 0.18ug/ml determined by ELISA. See testing image for detail.
Product Tag
 C-His
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Mouse LAG3, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Mouse FGL1, hFc Tag with the EC50 of 0.18ug/ml determined by ELISA.
Mouse LAG3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
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