Mouse LAG3/CD223 Protein (LAG-MM131)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Tris-Bis PAGE
Activity: Immobilized Mouse LAG3, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Mouse FGL1, hFc Tag with the EC50 of 0.18ug/ml determined by ELISA. See testing image for detail.
Exact Sequence: Ser23-Leu442

Catalog: LAG-MM131

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Product Description	Recombinant Mouse LAG3/CD223 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser23-Leu442.
Product Background	LAG-3, is a protein which in humans is encoded by the LAG3 gene, which is a cell surface molecule with diverse biologic effects on T cell function. It is an immune checkpoint receptor and as such is the target of various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders.
Product Category	Recombinant Protein

Target	LAG3/CD223
Synonyms	CD223; FDC; LAG3; LAG-3; sLAG-3
Gene/Protein ID	Q61790
Species	Mouse
Exact Sequence	Ser23-Leu442
Molecular Weight	The protein has a predicted MW of 46.2 kDa. Due to glycosylation, the protein migrates to 65-70 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Mouse LAG3, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Mouse FGL1, hFc Tag with the EC50 of 0.18ug/ml determined by ELISA. See testing image for detail.
Product Tag	C-His
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Mouse LAG3, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Mouse FGL1, hFc Tag with the EC50 of 0.18ug/ml determined by ELISA.
	Mouse LAG3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.