Mouse Siglec-3/CD33 Protein (CD3-MM133)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Exact Sequence: Asp18-Glu240

Catalog: CD3-MM133

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Product Description Recombinant Mouse Siglec-3/CD33 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asp18-Glu240.

Product Background

 Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state.They are sialoadhesin/CD169/Siglec-1, CD22/Siglec-2, CD33/Siglec-3, Myelin-Associated Glycoprotein (MAG/Siglec-4a) and Siglecs 5 to 11. To date, no Siglec has been shown to recognized any cell surface ligand other than sialic acids, suggesting that interactions with glycans containing this carbohydrate are important in mediating the biological functions of Siglecs.

Product Category

 Recombinant Protein

Target

 Siglec-3/CD33

Gene/Protein ID

 Q63994-1

Species

 Mouse

Exact Sequence

 Asp18-Glu240
Molecular Weight The protein has a predicted MW of 25.72 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.

Product Tag

 C-His

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Mouse Siglec-3 is greater than 95% as determined by SEC-HPLC.
Mouse Siglec-3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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