Mouse TRAIL R2/DR5/TNFRSF10B Protein (TRL-MM1R2)
Catalog: TRL-MM1R2
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| Product Description | Recombinant Mouse TRAIL R2/DR5/TNFRSF10B Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asn53-Lys180. |
Product Background |
DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. |
Product Category |
Recombinant Protein |
Target |
TRAIL R2/DR5/TNFRSF10B |
| Synonyms | CD262; DR5; DR5TRICK2B; Fas-like protein; KILLER/DR5; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRICK2; TRICK2A; TRICKB; ZTNFR9; KILLER |
Gene/Protein ID |
Q9QZM4-1 |
Species |
Mouse |
Exact Sequence |
Asn53-Lys180 |
| Molecular Weight | The protein has a predicted MW of 15.3 kDa. Due to glycosylation, the protein migrates to 30-40 kDa based on Tris-Bis PAGE result. |
Activity |
The affinity constant of 0.43 nM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by SEC-HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Mouse TRAIL R2, His Tag immobilized on CM5 Chip can bind Human TRAIL, No Tag with an affinity constant of 0.43 nM as determined in SPR assay (Biacore T200). |
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The purity of Mouse TRAIL R2 is greater than 95% as determined by SEC-HPLC. |
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Mouse TRAIL R2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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