ELISA binding curve showing dose-dependent interaction between rhesus macaque CDH17 protein and anti-CDH17 antibody.
Rhesus macaque CDH17/Cadherin 17 Protein (CDH-RM117)
Rhesus macaque CDH17/Cadherin 17 Protein (CDH-RM117)
Rhesus macaque CDH17/Cadherin 17 Protein (CDH-RM117)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Rhesus macaque CDH17, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Gln23-Thr784
Catalog #CDH-RM117
Regular price $346.50
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Rhesus macaque CDH17/Cadherin 17 Protein (CDH-RM117) Summary

Product Description

Recombinant Rhesus macaque CDH17/Cadherin 17 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln23-Thr784.

Product Background

Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Product Category

Recombinant Protein / Antibody discovery / Antibody discovery | Others

Rhesus macaque CDH17/Cadherin 17 Protein (CDH-RM117) Specifications/Details

Protein
CDH17/Cadherin 17
Synonyms
Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16; FLJ26931; MGC138218; MGC142024
Accession
Species
Rhesus macaque
Biotinylated
no
Amino Acid Range
Gln23-Thr784
Molecular Weight
The protein has a predicted MW of 85.60 kDa. Due to glycosylation, the protein migrates to 90-110 kDa based on Bis-Tris PAGE result.
Activity
Immobilized Rhesus macaque CDH17, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA. See testing image for detail.
Product Tag
C-His
Expression System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in 20mM Tris, 150mM NaCl (pH 8.0). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Immobilized Rhesus macaque CDH17, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA. Immobilized Rhesus macaque CDH17, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA.
Rhesus macaque CDH17 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Rhesus macaque CDH17 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Loaded Anti-CDH17 Antibody, hFc-Avi Tag on ProA-Biosensor can bind Rhesus macaque CDH17, His Tag with an affinity constant of 7.54 nM as determined in BLI assay (Gator® Prime). Loaded Anti-CDH17 Antibody, hFc-Avi Tag on ProA-Biosensor can bind Rhesus macaque CDH17, His Tag with an affinity constant of 7.54 nM as determined in BLI assay (Gator® Prime).
The purity of Rhesus macaque CDH17 is greater than 95% as determined by SEC-HPLC. The purity of Rhesus macaque CDH17 is greater than 95% as determined by SEC-HPLC.
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