Rhesus macaque CDH17/Cadherin 17 Protein (CDH-RM117)
Catalog: CDH-RM117
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| Product Description | Recombinant Rhesus macaque CDH17/Cadherin 17 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln23-Thr784. |
Product Background |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. |
Product Category |
Recombinant Protein |
Target |
CDH17/Cadherin 17 |
Gene/Protein ID |
A0A1D5R2B4 |
Species |
Rhesus macaque |
Exact Sequence |
Gln23-Thr784 |
| Molecular Weight | The protein has a predicted MW of 85.60 kDa. Due to glycosylation, the protein migrates to 90-110 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Rhesus macaque CDH17, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in 20mM Tris, 150mM NaCl (pH 8.0). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Immobilized Rhesus macaque CDH17, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA. |
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The purity of Rhesus macaque CDH17 is greater than 95% as determined by SEC-HPLC. |
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Rhesus macaque CDH17 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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