Name: Human TRAIL R2/DR5/TNFRSF10B Protein (TRL-HM4R2)
Brand: KactusBio
SKU: TRL-HM4R2-100UG
Price: 218.0 USD
Availability: InStock

Human TRAIL R2/DR5/TNFRSF10B Protein (TRL-HM4R2)

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human TRAIL R2, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-TRAIL R2 Antibody, hFc Tag with the EC50 of 3.4ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Ile56-Glu182

Catalog #TRL-HM4R2

Size

100UG

500UG

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Product Description	Recombinant Human TRAIL R2/DR5/TNFRSF10B Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Ile56-Glu182.
Product Background	DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Product Category	Recombinant Protein

Target	TRAIL R2/DR5/TNFRSF10B
Synonyms	CD262; DR5; DR5TRICK2B; Fas-like protein; KILLER/DR5; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRICK2; TRICK2A; TRICKB; ZTNFR9; KILLER
Accession	O14763-1
Species	Human
Biotinylated	no
Amino Acid Range	Ile56-Glu182
Molecular Weight	The protein has a predicted MW of 17.2 kDa. Due to glycosylation, the protein migrates to 20-25 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human TRAIL R2, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-TRAIL R2 Antibody, hFc Tag with the EC50 of 3.4ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His-Avi
Express System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Human TRAIL R2, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-TRAIL R2 Antibody, hFc Tag with the EC50 of 3.4ng/ml determined by ELISA.
	Human TRAIL R2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human TRAIL R2 is greater than 95% as determined by SEC-HPLC.

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