Name: Biotinylated Human Cystine/glutamate transporter (SLC7A11) Protein-Nanodisc (XCT-HM10NB)
Brand: KactusBio
SKU: XCT-HM10NB-100UG
Price: 2165.9 USD
Availability: InStock

Biotinylated Human Cystine/glutamate transporter (SLC7A11) Protein-Nanodisc (XCT-HM10NB)

Biotinylated Human SLC7A11 Nanodisc, His Tag captured on CM5 Chip via Streptavidin can bind Anti-SLC7A11 Antibody, hFc Tag with an affinity constant of 1.55 nM as determined in SPR assay (Biacore T200).

Immobilized Biotinylated Human SLC7A11 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-SLC7A11 Antibody, hFc Tag with the EC50 of 59.3ng/ml determined by ELISA (QC Test).

Express System: HEK293
Product Tag: C-His
Activity: Immobilized Biotinylated Human SLC7A11 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-SLC7A11 Antibody, hFc Tag with the EC50 of 59.3ng/ml determined by ELISA (QC Test). The affinity constant of 1.55 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Met1-Leu501

Catalog #XCT-HM10NB

Size

100UG

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Product Description	Recombinant Biotinylated Human Cystine/glutamate transporter (SLC7A11) Protein-Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Leu501.
Product Background	Solute Carrier Family 7 Member 11 (SLC7A11, also known as xCT) is the functional subunit of the Xc- system, an anionic L-cystine/L-glutamate antiporter expressed on the cell surface. SLC7A11 expression is significantly upregulated in several types of cancers in which it can inhibit ferroptosis and favor cancer cell proliferation, invasion and chemoresistance. SLC7A11 expression is also increased in ovarian cancer tissues, suggesting a possible role of this protein as a therapeutic target.
Product Category	Recombinant Protein / Antibody discovery / Multiple transmembrane proteins / Nanodisc

Protein	Cystine/glutamate transporter (SLC7A11)
Synonyms	Cystine/glutamate transporter; xCT; SLC7A11; CCBR1;
Accession	Q9UPY5
Species	Human
Biotinylated	yes
Amino Acid Range	Met1-Leu501
Molecular Weight	The protein has a predicted MW of 68.4 kDa.
Activity	Immobilized Biotinylated Human SLC7A11 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-SLC7A11 Antibody, hFc Tag with the EC50 of 59.3ng/ml determined by ELISA (QC Test). The affinity constant of 1.55 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS, 200mM L-Arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Stability And Storage	Valid for 6 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Biotinylated Human SLC7A11 Nanodisc, His Tag captured on CM5 Chip via Streptavidin can bind Anti-SLC7A11 Antibody, hFc Tag with an affinity constant of 1.55 nM as determined in SPR assay (Biacore T200).
	Immobilized Biotinylated Human SLC7A11 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-SLC7A11 Antibody, hFc Tag with the EC50 of 59.3ng/ml determined by ELISA (QC Test).