Name: Human Her2/ErbB2 Protein (HER-HM102)
Brand: KactusBio
SKU: HER-HM102-100UG
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human Her2, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-HER2 Antibody, hFc Tag with the EC50 of 2.7ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Thr23-Thr652

Catalog #HER-HM102

Size

100UG

500UG

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Product Description	Recombinant Human Her2/ErbB2 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Thr23-Thr652.
Product Background	ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors.Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane.
Product Category	Recombinant Protein / Antibody discovery / CAR-T targets

Protein	Her2/ErbB2
Synonyms	CD340; EGFR2; ErbB2; HER2; HER-2; herstatin; MLN 19; MLN19; NGL; TKR1; ERBB2; NEU; ENV; ENVW; ERVWE1; HERV7Q; HERVW
Accession	P04626-1
Species	Human
Biotinylated	no
Amino Acid Range	Thr23-Thr652
Molecular Weight	The protein has a predicted MW of 70.96 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human Her2, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-HER2 Antibody, hFc Tag with the EC50 of 2.7ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 0.1 EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human Her2, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-HER2 Antibody, hFc Tag with the EC50 of 2.7ng/ml determined by ELISA.
	Human Her2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human Her2 is greater than 95% as determined by SEC-HPLC.