Name: Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein (ITG-HM4V3)
Brand: KactusBio
SKU: ITG-HM4V3-100UG
Price: 412.5 USD
Availability: InStock

Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein (ITG-HM4V3)

Immobilized Human ITGAV&ITGB3, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-alpha V beta3 Antibody, hFc Tag with the EC50 of 3.5ng/ml determined by ELISA.

Human ITGAV&ITGB3 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

The purity of Human ITGAV&ITGB3-is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human ITGAV&ITGB3, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-alpha V beta3 Antibody, hFc Tag with the EC50 of 3.5ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Phe31-Val992(ITGAV) acidic tail & Gly27-Asp718(ITGB3) basic tail

Catalog #ITG-HM4V3

Size

100UG

500UG

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Product Description	Recombinant Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus of ITGAV.It contains Phe31-Val992 (ITGAV) acidic tail and Gly27-Asp718 (ITGB3) basic tail.
Product Background	ITGAV&ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV&ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV&ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV&ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV&ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Protein	Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer
Synonyms	αVβ3; Integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3;Integrin alpha V β 3; β3
Accession	P06756-1(ITGAV)&P05106-1(ITGB3)
Species	Human
Biotinylated	no
Amino Acid Range	Phe31-Val992(ITGAV) acidic tail & Gly27-Asp718(ITGB3) basic tail
Molecular Weight	The protein has a predicted MW of 114 kDa (ITGAV) & 81.3 kDa (ITGB3). Due to glycosylation,the protein migrates to 85-140 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human ITGAV&ITGB3, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-alpha V beta3 Antibody, hFc Tag with the EC50 of 3.5ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human ITGAV&ITGB3, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-alpha V beta3 Antibody, hFc Tag with the EC50 of 3.5ng/ml determined by ELISA.
	Human ITGAV&ITGB3 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.
	The purity of Human ITGAV&ITGB3-is greater than 95% as determined by SEC-HPLC.