Product Description |
Recombinant APC-equivalent Human HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer Protein is expressed from HEK293 with His tag at the C-terminus.It contains Gly25-Thr305 (HLA-G), Ile21-Met119 (B2M) and RIIPRHLQL peptide. |
Product Background |
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by the immune system of its mother, thus critically contributing to fetal-maternal tolerance. The first functional finding constituted the basis for HLA-G research and can be summarized as such: HLA-G, membrane-bound or soluble, strongly binds its inhibitory receptors on immune cells (NK, T, B, monocytes/dendritic cells), inhibits the functions of these effectors, and so induces immune inhibition. |
Product Category |
Recombinant Protein |
Target |
HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer |
MHC Form |
Tetramer |
Allele |
HLA-G |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Gly25-Thr305(HLA-G), Ile21-Met119(B2M) and RIIPRHLQL peptide |
Molecular Weight |
The protein has a predicted MW of 301.2 kDa. |
Activity |
Immobilized APC-equivalent Human HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-HLA-G&B2M&Peptide (RIIPRHLQL) Antibody, hFc Tag with the EC50 of 2.5ng/ml determined by ELISA (QC Test). See testing image for detail. |
Product Tag |
C-His |
Fluorophore |
APC |
Express System |
HEK293 |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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Immobilized APC-equivalent Human HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-HLA-G&B2M&Peptide (RIIPRHLQL) Antibody, hFc Tag with the EC50 of 2.5ng/ml determined by ELISA (QC Test). |
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Serial dilutions of Anti-LILRB2 Antibody were added into APC-equivalent Human HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer, His Tag: Human LILRB2, mFc Tag binding reactioins. The half maximal inhibitiory concentration (IC50) is 62.7 ng/ml. |
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