Biotinylated Human GPRC5D Protein-Nanodisc (GPR-HM45PB)
Catalog: GPR-HM45PB
Order now get it on
Product Description | Recombinant Biotinylated Human GPRC5D Protein-Nanodisc is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Met1-Val345. |
Product Background |
Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA. |
Product Category |
Recombinant Protein |
Target |
GPRC5D |
Accession | |
Species |
Human |
Amino Acid Range |
Met1-Val345 |
Molecular Weight | The protein has a predicted MW of 42.10 kDa. |
Activity |
Immobilized Anti-GPRC5D Antibody, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human GPRC5D Nanodisc, His Tag with the EC50 of 0.12ug/ml determined by ELISA (QC Test). The affinity constant of 6.30 nM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
C-His-Avi |
Express System |
HEK293 |
Endotoxin | Less than 1EU per ug by the LAL method. |
Form | Liquid |
Shipping | Shipped with dry ice. |
Formulation | Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage | Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
You may also be interested in
View more associated products