Name: Cynomolgus Coagulation factor XI Protein (pro form), Ultra Low Endotoxin (FXI-CM101-UL)
Brand: KactusBio
SKU: FXI-CM101-UL-100UG
Price: 429.0 USD
Availability: InStock

Cynomolgus Coagulation factor XI Protein (pro form), Ultra Low Endotoxin (FXI-CM101-UL)

Immobilized Cynomolgus Coagulation factor XI, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Factor XI Antibody, hFc Tag with the EC50 of 4.9ng/ml determined by ELISA (QC Test).

Cynomolgus Coagulation factor XI on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Cynomolgus Coagulation factor XI Protein is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Cynomolgus Coagulation factor XI, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Factor XI Antibody, hFc Tag with the EC50 of 4.9ng/ml determined by ELISA (QC Test). See testing image for detail.Measured by its ability to cleave the fluorogenic peptide substrate, t-butyloxycarbonyl-Ile-Glu-Gly-Arg-7-amido-4-methylcoumarin (Boc-IEGR-AMC). The specific activity is >50 pmoles/min/ug.
Amino Acid Range: Glu44-Ala650

Catalog #FXI-CM101-UL

Size

100UG

500UG

Order by 4pm ET for delivery on:

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Cynomolgus Coagulation factor XI Protein (pro form), Ultra Low Endotoxin (FXI-CM101-UL) Summary

Product Description	Recombinant Cynomolgus Coagulation factor XI Protein is expressed from HEK293 with His tag at the C-Terminus. The protein needs to be activated by Thermolysin for an activated form.It contains Glu44-Ala650.
Product Background	Factor XI (FXI) is the zymogen of a plasma protease (FXIa) that contributes to hemostasis by activating factor IX (FIX). In the original cascade model of coagulation, FXI is converted to FXIa by factor XIIa (FXIIa), a component, along with prekallikrein and high-molecular-weight kininogen (HK), of the plasma kallikrein-kinin system (KKS).
Product Category	Recombinant Protein / Cell therapy / Cell culture / Cytokines

Cynomolgus Coagulation factor XI Protein (pro form), Ultra Low Endotoxin (FXI-CM101-UL) Specifications/Details

Protein	Coagulation factor XI
Synonyms	FXI; PTA; F11; Coagulation factor XI
Accession	XP_005556540.2
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Glu44-Ala650
Molecular Weight	The protein has a predicted MW of 69.05 kDa. Due to glycosylation, the protein migrates to 70-85 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus Coagulation factor XI, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Factor XI Antibody, hFc Tag with the EC50 of 4.9ng/ml determined by ELISA (QC Test). See testing image for detail.Measured by its ability to cleave the fluorogenic peptide substrate, t-butyloxycarbonyl-Ile-Glu-Gly-Arg-7-amido-4-methylcoumarin (Boc-IEGR-AMC). The specific activity is >50 pmoles/min/ug.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 0.01 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Immobilized Cynomolgus Coagulation factor XI, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Factor XI Antibody, hFc Tag with the EC50 of 4.9ng/ml determined by ELISA (QC Test).
	Cynomolgus Coagulation factor XI on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Cynomolgus Coagulation factor XI Protein is greater than 95% as determined by SEC-HPLC.