Human CD20 Protein-Nanodisc (CD2-HM1N37)

  • Express System: HEK293
  • Product Tag: C-His
  • Activity: Immobilized Rituximab, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human CD20 Nanodisc, His Tag with the EC50 of 70.6ng/ml determined by ELISA (QC Test). The affinity constant of 3.09 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Met1-Pro297

Catalog: CD2-HM1N37

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Product Description Recombinant Human CD20 Protein-Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Pro297.

Product Background

B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R , CD117) and progressively increasing in concentration until maturity.CD20 is the target of the monoclonal antibodies rituximab, ocrelizumab, obinutuzumab, ofatumumab, ibritumomab tiuxetan, tositumomab, and ublituximab, which are all active agents in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases.

Product Category

Recombinant Protein

Target

CD20 Nanodisc
Accession

Species

Human

Amino Acid Range

Met1-Pro297
Molecular Weight The protein has a predicted MW of 34.3 kDa kDa.

Activity

Immobilized Rituximab, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human CD20 Nanodisc, His Tag with the EC50 of 70.6ng/ml determined by ELISA (QC Test). The affinity constant of 3.09 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

C-His

Express System

HEK293
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22 um filtered solution in PBS (pH 7.4). Notice: Not recommended for immunization and FACS.
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human CD20 Nanodisc, His Tag captured on CM5 Chip via anti-his antibody can bind Rituximab, hFc Tag with an affinity constant of 3.09 nM as determined in SPR assay (Biacore T200).
Human CD20 Nanodisc, His Tag captured on CM5 Chip via anti-his antibody can bind Ofatumumab, hFc Tag with an affinity constant of 153.07 nM as determined in SPR assay (Biacore T200).
Immobilized Rituximab, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human CD20 Nanodisc, His Tag with the EC50 of 70.6ng/ml determined by ELISA (QC Test).
Immobilized Human CD20 Nanodisc, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Obinutuzumab, hFc Tag with the EC50 of 35.3ng/ml determined by ELISA.

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