Name: Human CD20 Protein-Nanodisc (CD2-HM1N37)
Brand: KactusBio
SKU: CD2-HM1N37-100UG
Price: 1210.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Activity: Immobilized Rituximab, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human CD20 Nanodisc, His Tag with the EC50 of 14.6ng/ml determined by ELISA (QC Test). The affinity constant of 3.09 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Met1-Pro297

Catalog #CD2-HM1N37

Size

100UG

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Product Description	Recombinant Human CD20 Protein-Nanodisc is expressed from HEK293 with His tag at the C-terminus (FITC-equivalent protein is fused on cytoplasmic part).It contains Met1-Pro297.
Product Background	B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R , CD117) and progressively increasing in concentration until maturity.CD20 is the target of the monoclonal antibodies rituximab, ocrelizumab, obinutuzumab, ofatumumab, ibritumomab tiuxetan, tositumomab, and ublituximab, which are all active agents in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases.
Product Category	Recombinant Protein / Antibody discovery / Multiple transmembrane proteins / Nanodisc

Protein	CD20
Synonyms	MS4A1; CD20; MS4A-1; B1; Bp35; CD20 receptor; CD20S7; CVID5; LEU-16; Ly-44; MS4A2; S7
Accession	P11836-1
Species	Human
Biotinylated	no
Amino Acid Range	Met1-Pro297
Molecular Weight	The protein has a predicted MW of 34.3 kDa.
Activity	Immobilized Rituximab, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human CD20 Nanodisc, His Tag with the EC50 of 14.6ng/ml determined by ELISA (QC Test). The affinity constant of 3.09 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human CD20 Nanodisc, His Tag captured on CM5 Chip via anti-his antibody can bind Rituximab, hFc Tag with an affinity constant of 3.09 nM as determined in SPR assay (Biacore T200).
	Human CD20 Nanodisc, His Tag captured on CM5 Chip via anti-his antibody can bind Ofatumumab, hFc Tag with an affinity constant of 153.07 nM as determined in SPR assay (Biacore T200).
	Immobilized Rituximab, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human CD20 Nanodisc, His Tag with the EC50 of 14.6ng/ml determined by ELISA (QC Test).
	Immobilized Human CD20 Nanodisc, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Obinutuzumab, hFc Tag with the EC50 of 35.3ng/ml determined by ELISA.