Name: Non-biotinylated Human Her2/ErbB2 Protein (HER-HM402)
Brand: KactusBio
SKU: HER-HM402-100UG
Price: 330.0 USD
Availability: InStock

ELISA binding curve for recombinant human Her2 (ERBB2) protein with His tag, showing interaction with anti-Her2 antibody (hFc tag). Graph plots absorbance (OD450) vs. antibody concentration, demonstrating Her2 binding activity.

Non-biotinylated Human Her2/ErbB2 Protein (HER-HM402)

Immobilized Human Her2, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Her2 Antibody, hFc Tag with the EC50 of 7.4ng/ml determined by ELISA (QC Test).

Human Her2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Loaded Anti-HER2 Antibody on ProA-Biosensor can bind Human Her2, His Tag with an affinity constant of 32 nM as determined in BLI assay (Gator® Prime).

The purity of Human Her2 is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human Her2, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Her2 Antibody, hFc Tag with the EC50 of 7.4ng/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Thr23-Thr652

Catalog #HER-HM402

Size

100UG

500UG

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Product Description	Recombinant Human Her2/ErbB2 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Thr23-Thr652.
Product Background	ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors.Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane.
Product Category	Recombinant Protein / Antibody discovery / CAR-T targets

Protein	Her2/ErbB2
Synonyms	CD340; EGFR2; ErbB2; HER2; HER-2; herstatin; MLN 19; MLN19; NGL; TKR1; ERBB2; NEU; ENV; ENVW; ERVWE1; HERV7Q; HERVW
Accession	P04626-1
Species	Human
Biotinylated	no
Amino Acid Range	Thr23-Thr652
Molecular Weight	The protein has a predicted MW of 72.3 kDa. Due to glycosylation, the protein migrates to 80-100 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human Her2, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Her2 Antibody, hFc Tag with the EC50 of 7.4ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human Her2, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Her2 Antibody, hFc Tag with the EC50 of 7.4ng/ml determined by ELISA (QC Test).
	Human Her2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	Loaded Anti-HER2 Antibody on ProA-Biosensor can bind Human Her2, His Tag with an affinity constant of 32 nM as determined in BLI assay (Gator® Prime).
	The purity of Human Her2 is greater than 95% as determined by SEC-HPLC.

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