Human Latent TGF beta 2/TGFB2 Protein (TGF-HM102)
Catalog: TGF-HM102
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| Product Description | Recombinant Human Latent TGF beta 2/TGFB2 Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Leu21-Ser414. |
Product Background |
Transforming growth factor beta(2) (TGF-beta(2)), a growth regulator of human lens epithelial cells (HLECs), also regulates the death of these cells. TGF-beta(2)-induced apoptosis in HLECs was preceded by an induction of reactive oxygen species (ROS) and a decrease in glutathione in the intracellular content, indicating that this factor induces oxidative stress in HLECs. |
Product Category |
Recombinant Protein |
Target |
Latent TGF beta 2/TGFB2 |
| Synonyms | TGFB2; TGFBR2; TGFR2; TbetaR-II; TGFβR2; BB105277; TGF-beta 2 |
Gene/Protein ID |
P61812-1 |
Species |
Human |
Exact Sequence |
Leu21-Ser414 |
| Molecular Weight | The protein has a predicted MW of 46.6 kDa. Due to glycosylation, the protein migrates to 40-60 kDa&12-13 kDa based on Tris-Bis PAGE result. |
Activity |
The affinity constant of 2.21 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
N-His |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Human TGF-beta RII, hFc Tag captured on CM5 Chip via Protein A can bind Human Latent TGF beta 2, His Tag with an affinity constant of 2.21 uM as determined in SPR assay (Biacore T200). |
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The purity of Human Latent TGF beta 2 is greater than 95% as determined by SEC-HPLC. |
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Human Latent TGF beta 2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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