Human Latent TGF beta 2/TGFB2 Protein (TGF-HM102)

  • Express System: HEK293
  • Product Tag: N-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 2.21 uM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Leu21-Ser414

Catalog: TGF-HM102

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Product Description Recombinant Human Latent TGF beta 2/TGFB2 Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Leu21-Ser414.

Product Background

Transforming growth factor beta(2) (TGF-beta(2)), a growth regulator of human lens epithelial cells (HLECs), also regulates the death of these cells. TGF-beta(2)-induced apoptosis in HLECs was preceded by an induction of reactive oxygen species (ROS) and a decrease in glutathione in the intracellular content, indicating that this factor induces oxidative stress in HLECs.

Product Category

Recombinant Protein

Target

Latent TGF beta 2/TGFB2
Synonyms TGFB2; TGFBR2; TGFR2; TbetaR-II; TGFβR2; BB105277; TGF-beta 2
Accession

Species

Human

Amino Acid Range

Leu21-Ser414
Molecular Weight The protein has a predicted MW of 46.6 kDa. Due to glycosylation, the protein migrates to 40-60 kDa&12-13 kDa based on Tris-Bis PAGE result.

Activity

The affinity constant of 2.21 uM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

N-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human TGF-beta RII, hFc Tag captured on CM5 Chip via Protein A can bind Human Latent TGF beta 2, His Tag with an affinity constant of 2.21 uM as determined in SPR assay (Biacore T200).
The purity of Human Latent TGF beta 2 is greater than 95% as determined by SEC-HPLC.
Human Latent TGF beta 2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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