Name: Human LGMN Protein (LGM-HM101)
Brand: KactusBio
SKU: LGM-HM101-100UG
Price: 264.0 USD
Availability: InStock

Catalog #LGM-HM101

Size

100UG

500UG

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Human LGMN Protein (LGM-HM101) Summary

Product Description	Recombinant Human LGMN Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Val18-Tyr433.
Product Background	Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Human LGMN Protein (LGM-HM101) Specifications/Details

Protein	LGMN
Synonyms	Legumain; Prsc1; AEP; LGMN; LGMN1; AI746452; AU022324
Accession	Q99538-1
Species	Human
Biotinylated	no
Amino Acid Range	Val18-Tyr433
Molecular Weight	The protein has a predicted MW of 48.6 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.
Product Tag	N-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22um filtered solution in 50mM Tris, 50mM NaCl, 10% glycerol (pH 7.5).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.