Name: Human LOX1 Protein (LOX-HM101)
Brand: KactusBio
SKU: LOX-HM101-100UG
Price: 297.0 USD
Availability: InStock

Express System: HEK293
Product Tag: N-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human LOX1, His Tag at 0.5ug/ml(100ul/well) on the plate. Dose response curve for Anti-LOX1 Antibody, hFc Tag with the EC50 of 1.8ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Ser61-Gln273

Catalog #LOX-HM101

Size

100UG

500UG

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Product Description	Recombinant Human LOX1 Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Ser61-Gln273.
Product Background	LOX-1 is a transmembrane glycoprotein that binds to and internalizes ox-LDL.LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atherosclerosis. LOX-1 deletion also results in damage from ischemia, making LOX-1 a promising target of therapy for atherosclerosis and related disorders. In this article we focus on the different mechanisms for regulation, signaling and the various effects of LOX-1 in contributing to atherosclerosis.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Protein	LOX1
Synonyms	Ox-LDL receptor 1; LOX-1; CLEC8A; LOX1; OLR1; LOXIN; SR-E1; SCARE1; SLOX1
Accession	P78380-1
Species	Human
Biotinylated	no
Amino Acid Range	Ser61-Gln273
Molecular Weight	The protein has a predicted MW of 25.4 kDa. Due to glycosylation, the protein migrates to 30-36 kDa under reduced condition and 60-70 kDa under Non reduced (N) condition based on Bis-Tris PAGE result.
Activity	Immobilized Human LOX1, His Tag at 0.5ug/ml(100ul/well) on the plate. Dose response curve for Anti-LOX1 Antibody, hFc Tag with the EC50 of 1.8ng/ml determined by ELISA. See testing image for detail.
Product Tag	N-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human LOX1, His Tag at 0.5ug/ml(100ul/well) on the plate. Dose response curve for Anti-LOX1 Antibody, hFc Tag with the EC50 of 1.8ng/ml determined by ELISA.
	Human LOX1 on Bis-Tris PAGE under reduced condition and Non reduced (N) condition. The purity is greater than 95%.
	The purity of Human LOX1 is greater than 95% as determined by SEC-HPLC.