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Human TRAIL R1/DR4/TNFRSF10A Protein (TRL-HM2R1) Summary
Product Description |
Recombinant Human TRAIL R1/DR4/TNFRSF10A Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Ala24-Asn239. |
Product Background |
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis selectively via its interaction with the death receptors TRAILR1/DR4 and TRAILR2/DR5 in a wide range of cancers, while sparing normal cells. Despite its tremendous potential for cancer therapeutics, the translation of TRAIL into the clinic has been confounded by TRAIL-resistant cancer populations. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Human TRAIL R1/DR4/TNFRSF10A Protein (TRL-HM2R1) Specifications/Details
Protein |
TRAIL R1/DR4/TNFRSF10A |
Synonyms |
DR4; CD261; TNFRSF10A; TRAIL-R; APO2; TRAIL R1; MGC9365 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Ala24-Asn239 |
Molecular Weight |
The protein has a predicted MW of 48.8 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human TRAIL, No Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human TRAIL R1, hFc Tag with the EC50 of 11.1ng/ml determined by ELISA. |
Product Tag |
C-hFc (IgG1) |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Human TRAIL, No Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human TRAIL R1, hFc Tag with the EC50 of 11.1ng/ml determined by ELISA. |
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Human TRAIL R1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human TRAIL R1 is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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