Human TRAIL R1/DR4/TNFRSF10A Protein (TRL-HM2R1)

  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human TRAIL, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human TRAIL R1, hFc Tag with the EC50 of 51.6ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Pro34-Asn239

Catalog: TRL-HM2R1

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Product Description Recombinant Human TRAIL R1/DR4/TNFRSF10A Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Pro34-Asn239.

Product Background

 Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis selectively via its interaction with the death receptors TRAILR1/DR4 and TRAILR2/DR5 in a wide range of cancers, while sparing normal cells. Despite its tremendous potential for cancer therapeutics, the translation of TRAIL into the clinic has been confounded by TRAIL-resistant cancer populations.

Product Category

 Recombinant Protein

Target

 TRAIL R1/DR4/TNFRSF10A
Synonyms DR4; CD261; TNFRSF10A; TRAIL-R; APO2; TRAIL R1; MGC9365

Gene/Protein ID

 O00220

Species

 Human

Exact Sequence

 Pro34-Asn239
Molecular Weight The protein has a predicted MW of 48.8 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.

Activity

 Immobilized Human TRAIL, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human TRAIL R1, hFc Tag with the EC50 of 51.6ng/ml determined by ELISA. See testing image for detail.

Product Tag

 C-hFc

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human TRAIL, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human TRAIL R1, hFc Tag with the EC50 of 51.6ng/ml determined by ELISA.
The purity of Human TRAIL R1 is greater than 95% as determined by SEC-HPLC.
Human TRAIL R1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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