Human ITCH Protein (ITH-HE001)

  • Express System: E.coli
  • Product Tag: No Tag
  • Purity: > 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
  • Exact Sequence: Arg485-Glu862

Catalog: ITH-HE001

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Product Description Recombinant Human ITCH Protein is expressed from E.coli without tag.It contains Arg485-Glu862.

Product Background

 Itch or itchy E3 is a member of the homologous to E6-associated protein C-terminus (HECT)-type family of E3 ligases, with the protein-interacting WW-domains for the recruitment of substrate and the HECT domain for the transfer of ubiquitin to the substrate, and its deletion results in an itchy phenotype with constant skin scratching and multi-organ inflammation.

Product Category

 Recombinant Protein

Target

 ITCH

Gene/Protein ID

 NP_113671.3

Species

 Human

Exact Sequence

 Arg485-Glu862
Molecular Weight The protein has a predicted MW of 44.98 kDa same as Tris-Bis PAGE result.

Product Tag

 No Tag

Express System

 E.coli
Purity > 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22 um filtered solution in PBS, 200mM L-Arginine (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Human ITCH is greater than 90% as determined by SEC-HPLC.
Human ITCH on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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