Mouse IFN alpha/beta R1 Protein (IFN-MM2R1)
Mouse IFN alpha/beta R1 Protein (IFN-MM2R1)
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 20.35 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Glu27-Thr429
Catalog #IFN-MM2R1
Regular price $300.00
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Product Description

Recombinant Mouse IFN alpha/beta R1 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Glu27-Thr429.

Product Background

IFN-alpha / beta R1, also known as IFNAR1, belongs to the class II cytokine receptor family of proteins. Class II cytokine receptors form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions.Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves.

Product Category

Recombinant Protein / Antibody discovery

Protein

IFN alpha/beta R1

Synonyms

AVP; IFN-alpha/beta R1; IFN-alpha-REC; IFNAR; IFNAR1; IFN-aR1; IFNBR; IFNbR1; IFN-R-1; CRF2-1; IFRC ; IFN-alpha/β R1

Accession

Species

Mouse

Biotinylated

no

Amino Acid Range

Glu27-Thr429

Molecular Weight

The protein has a predicted MW of 72.5 kDa. Due to glycosylation, the protein migrates to 83-110 kDa based on Bis-Tris PAGE result.

Activity

The affinity constant of 20.35 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

C-hFc

Expression System

HEK293

Purity

> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC

Endotoxin

Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Mouse IFN alpha/beta R1, hFc Tag immobilized on CM5 Chip can bind Human IFN alpha 1, hFc Tag with an affinity constant of 20.35 nM as determined in SPR assay (Biacore T200). Mouse IFN alpha/beta R1, hFc Tag immobilized on CM5 Chip can bind Human IFN alpha 1, hFc Tag with an affinity constant of 20.35 nM as determined in SPR assay (Biacore T200).
Mouse IFNAR1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Mouse IFNAR1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Mouse IFNAR1 is greater than 95% as determined by SEC-HPLC. The purity of Mouse IFNAR1 is greater than 95% as determined by SEC-HPLC.

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