Mouse IFN alpha/beta R1 Protein (IFN-MM2R1)

Express System: HEK293
Product Tag: C-hFc
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: The affinity constant of 20.35 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Exact Sequence: Glu27-Thr429

Catalog: IFN-MM2R1

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Product Description	Recombinant Mouse IFN alpha/beta R1 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Glu27-Thr429.
Product Background	IFN-alpha / beta R1, also known as IFNAR1, belongs to the class II cytokine receptor family of proteins. Class II cytokine receptors form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions.Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves.
Product Category	Recombinant Protein

Target	IFN alpha/beta R1
Synonyms	AVP; IFN-alpha/beta R1; IFN-alpha-REC; IFNAR; IFNAR1; IFN-aR1; IFNBR; IFNbR1; IFN-R-1; CRF2-1; IFRC
Gene/Protein ID	P33896
Species	Mouse
Exact Sequence	Glu27-Thr429
Molecular Weight	The protein has a predicted MW of 72.5 kDa. Due to glycosylation, the protein migrates to 83-110 kDa based on Tris-Bis PAGE result.
Activity	The affinity constant of 20.35 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-hFc
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Mouse IFN alpha/beta R1, hFc Tag immobilized on CM5 Chip can bind Human IFN alpha 1, hFc Tag with an affinity constant of 20.35 nM as determined in SPR assay (Biacore T200).
	The purity of Mouse IFNAR1 is greater than 95% as determined by SEC-HPLC.
	Mouse IFNAR1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.