Mouse TMEM106B Protein (TEM-MM26B)
Mouse TMEM106B Protein (TEM-MM26B)
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Pro119-Gln275
Catalog #TEM-MM26B
Regular price $270.00
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Product Description
Recombinant Mouse TMEM106B Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Pro119-Gln275.
Product Background
TMEM106B is a well-recognised risk factor for FTD caused by GRN mutation. Elegant experiments have suggested that increased risk for FTD is due to elevated levels of TMEM106B (Nicholson et al, 2013; Gallagher et al, 2017). Therefore, recent work has explored the therapeutic potential of reducing TMEM106B levels, with initial results looking encouraging, as crossing a Grn-deficient mouse to a Tmem106b knockout showed a rescue in FTD-related behavioural defects and specific aspects of lysosome dysfunction (Klein et al, 2017).
Product Category
Recombinant Protein
Target
TMEM106B
Synonyms
Transmembrane protein 106B;Tmem106b
Accession
Species
Mouse
Biotinylated
no
Amino Acid Range
Pro119-Gln275
Molecular Weight
The protein has a predicted MW of 44.8 kDa. Due to glycosylation, the protein migrates to 65-68 kDa based on Bis-Tris PAGE result.
Product Tag
C-hFc
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Mouse TMEM106B on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Mouse TMEM106B is greater than 95% as determined by SEC-HPLC.

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