Mouse TMEM106B Protein (TEM-MM26B)
Mouse TMEM106B Protein (TEM-MM26B)
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Pro119-Gln275
Catalog #TEM-MM26B
Regular price $297.00
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Product Description

Recombinant Mouse TMEM106B Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Pro119-Gln275.

Product Background

TMEM106B is a well-recognised risk factor for FTD caused by GRN mutation. Elegant experiments have suggested that increased risk for FTD is due to elevated levels of TMEM106B (Nicholson et al, 2013; Gallagher et al, 2017). Therefore, recent work has explored the therapeutic potential of reducing TMEM106B levels, with initial results looking encouraging, as crossing a Grn-deficient mouse to a Tmem106b knockout showed a rescue in FTD-related behavioural defects and specific aspects of lysosome dysfunction (Klein et al, 2017).

Product Category

Recombinant Protein / Antibody discovery / Antibody discovery | Others

Protein

TMEM106B

Synonyms

Transmembrane protein 106B;Tmem106b

Accession

Species

Mouse

Biotinylated

no

Amino Acid Range

Pro119-Gln275

Molecular Weight

The protein has a predicted MW of 44.8 kDa. Due to glycosylation, the protein migrates to 65-68 kDa based on Bis-Tris PAGE result.

Product Tag

C-hFc

Expression System

HEK293

Purity

> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC

Endotoxin

Less than 1 EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Mouse TMEM106B on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Mouse TMEM106B on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Mouse TMEM106B is greater than 95% as determined by SEC-HPLC. The purity of Mouse TMEM106B is greater than 95% as determined by SEC-HPLC.

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