Name: Mouse TMEM106B Protein (TEM-MM26B)
Brand: KactusBio
SKU: TEM-MM26B-100UG
Price: 270.0 USD
Availability: InStock

Catalog #TEM-MM26B

Size

100UG

500UG

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Product Description	Recombinant Mouse TMEM106B Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Pro119-Gln275.
Product Background	TMEM106B is a well-recognised risk factor for FTD caused by GRN mutation. Elegant experiments have suggested that increased risk for FTD is due to elevated levels of TMEM106B (Nicholson et al, 2013; Gallagher et al, 2017). Therefore, recent work has explored the therapeutic potential of reducing TMEM106B levels, with initial results looking encouraging, as crossing a Grn-deficient mouse to a Tmem106b knockout showed a rescue in FTD-related behavioural defects and specific aspects of lysosome dysfunction (Klein et al, 2017).
Product Category	Recombinant Protein / Antibody discovery

Protein	TMEM106B
Synonyms	Transmembrane protein 106B;Tmem106b
Accession	Q80X71
Species	Mouse
Biotinylated	no
Amino Acid Range	Pro119-Gln275
Molecular Weight	The protein has a predicted MW of 44.8 kDa. Due to glycosylation, the protein migrates to 65-68 kDa based on Bis-Tris PAGE result.
Product Tag	C-hFc
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Mouse TMEM106B on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Mouse TMEM106B is greater than 95% as determined by SEC-HPLC.